Problem-Based Microbiology by Swapan K. Nath
Author:Swapan K. Nath [Swapan K. Nath, PhD, F(CCM), Sanjay G. Revankar, MD]
Language: eng
Format: epub
ISBN: 978-1-455-70533-7
Publisher: Elsevier Health Sciences
Published: 2006-09-22T04:00:00+00:00
Imaging
Head MRI revealed ring-enhancing lesions in the left parietal lobe and right frontal lobe (Fig. 63-1).
FIGURE 63-1 Head MRI scan of this patient with seizure illness. Note ring-enhancing lesions in the left parietal lobe and right frontal lobe in this patient.
(Courtesy of Dr. Daniel Skiest, Department of Medicine, University of Texas Southwestern Medical Center, Dallas, TX.)
Diagnostic Work-Up
Table 63-1 lists the likely causes of illness (differential diagnosis). A clinical diagnosis of encephalitis was considered based on the evidence of brain lesions. Investigational approach may include
• Cultures of blood and CSF for bacteria and Cryptococcus neoformans
• Serology. A significantly high titer of IgG specific for Toxoplasma gondii in a single serum may support the diagnosis of Toxoplasma encephalitis.
• In failed investigation, the following tests can be undertaken: • Histology of brain biopsy
• Detection of genetic material by PCR in CSF and biopsy
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